Deliver the active ingredient through your skin and eventually into your bloodstream. Transdermal patches were invented by Alejandro Zaffaroni, he received his patents on transdermal systemic drug delivery in the early 1970s. The most common and successful use of transdermal patches has been with nicotine in the fight to quit smoking.
Is it a gimmick? No not at all, transdermal patches have been used to deliver prescription grade drugs.
There are many advantages to using a transdermal patch over taking pills, one very important advantage of using patches over the traditional ‘pill’ is the active ingredients don’t pass through your digestive system making them more bioavailable.
A large proportion of the active ingredients in a pill can be lost to ‘First Pass’ (your digestive system) whereas the ingredients from a patch pass directly into your epidermis and into your bloodstream.
The obvious advantage is if you don't like taking pills or you find them troublesome with your digestion or they disagree with you in some way using a patch can be of enormous benefit
Your skin (epidermis)
How it works
Transdermal patches deliver active ingredients to your bloodstream in the following manner. The patch is applied to the skin the natural heat from your skin triggers the pores present in the upper layer of the skin that causes water to be drawn out of cells into the blood capillaries surrounding it. This increases blood flow to that area. Molecules of the active ingredient pass through these pores directly into your bloodstream when you place a Lifebio patch on your body. In this way, transdermal technology allows active ingredients to be delivered very effectively with no pain while simultaneously ensuring that they are penetrating deep into your body tissues.
Backed by science
The skin is the largest organ in the human body by mass, with an area of between 1.5 and 2.0 m2 in adults. Drugs have been applied to the skin to treat superficial disorders, for the transdermal administration of therapeutics to manage systemic ailments and as cosmetics, dating back to the oldest existing medical records of man. For instance, the use of salves, ointments, potions and even patches, consisting of plant, animal or mineral extracts, was already popular in ancient Egypt and in Babylonian medicine (around 3000 BC).
However, the routine use of transdermal delivery systems only became a common practice in the latter third of the 20th century when delivery technology was developed to enable precise and reproducible administration through the skin for systemic effects.
Alejandro Zaffaroni was a biotechnology innovator whose early work with controlled drug delivery methods, particularly his early concepts for transdermal patches, led to the growth of research into innovative drug delivery systems.
Zaffaroni founded ALZA Corporation in 1968 to pursue his ideas for controlled drug delivery systems. His first innovations at ALZA included a thin film for the eye for glaucoma treatment and a contraceptive device that released progesterone. Zaffaroni received his patents on transdermal systemic drug delivery in the early 1970s. In 1981, ALZA worked with the Swiss company Ciba-Geigy, and the FDA approved the first transdermal delivery system with scopolamine, Transderm-Scop®, for motion sickness, followed closely by Transderm-Nitro® for angina. ALZA ultimately brought over 20 prescription products to market before being acquired by Johnson & Johnson.
Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence‐based studies that date back to the first existing human records.
Proof patches work
To date, the FDA has approved more than 40 transdermal products containing substances such as nicotine, hormones, pain medications, and antidepressants.
Probably the best known application for transdermal patches in recent times has been in the form of Nicotine patches as a way of quitting smoking.
Until recently patches were used for prescription grade drug delivery and not for over the counter remedies and vitamins.
The word ‘Bioavailability’ is often used when describing the advantages of transdermal patches. What does higher bioavailability mean?
According to the National Institute of Health's Office of Dietary Supplements, bioavailability refers to the amount of (the nutrient) in food, medications, and supplements that is absorbed in the intestines and ultimately available for biological activity in your cells and tissues. ...
Advantages of patches over traditional delivery systems
Patches offer ‘High Bioavailability’ because the active ingredients pass through the skin and directly into your bloodstream.
Administration of therapeutic agents across the skin enables drugs to avoid first‐pass (your metabolism) chemical or enzymatic degradation in the gastrointestinal tract or liver where for example capsules (pills) might lose a large amount of their effectiveness when passing through your metabolism.
The UK government recommended daily dose is woefully low at 400IU.
Most of us are deficient in Vitamin D, People living more than 35° latitude away from the equator, including the UK (London, latitude 51.5°), are unlikely to receive sufficient UVB to avoid insufficiency without supplementation.
Consequently, vitamin D levels in the UK in February are about 50% of those in September. Pollution, particularly sulfur dioxide, can block UVB substantially. Sunscreen blocks UVB radiation but it is thought unlikely that conventional use of sunscreen causes vitamin D deficiency but will act as a barrier to the new production of vitamin D.
People with limited outdoor exposure or who routinely wear more extensive clothing will have reduced vitamin D synthesis and this presumably accounts for the surprisingly high rates of vitamin D deficiency in some countries nearer the equator.
An important letter signed by over 200 Scientists & Doctors called for “Increased Vitamin D Use To Combat COVID-19”
It is interesting to note that these experts all recommend a higher daily intake of Vitamin D than that suggested by the UK government and that their own daily intake often exceeds that of 4000IU and some take 10,000IU one takes 50,000IU daily.
You are in control
Take control of our own immunity by boosting it with a more realistic dose of vitamin D, our patches will do the job eminently well, simply and easily.
There are many other claims being made associated with vitamin deficiencies. If you shun the sun, suffer from milk allergies, or adhere to a strict vegan diet, you may be at risk for vitamin D deficiency. When you consider how much time we spend indoors in front of a computer screen then it should come as no surprise we are all lacking in vitamin D.
Known as the sunshine vitamin, vitamin D is produced by the body in response to skin being exposed to sunlight. It also occurs naturally in a few foods -- including some fish, fish liver oils, and egg yolks -- and in fortified dairy and grain products. Vitamin D is essential for strong bones, because it helps the body use calcium from the diet. Traditionally, vitamin D deficiency has been associated with rickets, a disease in which the bone tissue doesn't properly mineralize, leading to soft bones and skeletal deformities. But increasingly, research is revealing the importance of vitamin D in protecting against a host of health problems.
Health Risks of Vitamin D Deficiency
Symptoms and Health Risks of Vitamin D Deficiency
Symptoms of bone pain and muscle weakness can mean you have a vitamin D deficiency. However, for many people, the symptoms are subtle. Yet, even without symptoms, too little vitamin D can pose health risks. Low blood levels of the vitamin have been associated with the following:
Increased risk of death from cardiovascular disease
Cognitive impairment in older adults
Severe asthma in children
Certain types of Cancer
Research suggests that vitamin D could play a role in the prevention and treatment of a number of different conditions, including type1 and type 2 diabetes, hypertension, glucose intolerance, and multiple sclerosis.
Primarily vitamin B12 was added to the formula for energy!
We like that our patches effects can be felt usually very quickly, we wear our patches daily and we feel the benefit of the B12 especially after lunch…the graveyard zone of productivity ;-)
I no longer drink a large espresso after lunch, my Boost & Protect patch takes its place.
Vitamin B12 contributes to the reduction of tiredness and fatigue, to normal neurological and psychological functions and contributes to normal homocysteine metabolism.
Vitamin B12 does a lot of things for your body. It helps make your DNA and your red blood cells, for example.
Since your body doesn't make vitamin B12, you used to have to get it from animal-based foods.
The vitamin B12 used in our patches is synthetic Cyanocobalamin and is recommended by the Vegan Society, mainly because it is the most stable type. Your body converts it to the two active forms of vitamin B12, which are methylcobalamin and adenosylcobalamin.
All of the above couple with high bioavailability and the almost immediate delivery into your bloodstream transdermal patches have to be the way forward